-- Is faster always better when choosing ammunition? Yes and no. Always consider more than just the velocity of a caliber or cartridge when looking for your best venison taker. Think about the kind of shots you'll be taking.
Do you plan any long distance shooting? If so, more velocity will mean flatter trajectory and longer range capability. Look at smaller diameter calibers like the .25-06, .270 Win., .270 WSM and .280 Rem. And if you'll be after big mule deer, it might not hurt to move up to .300 Win Mag, .30-06, .300 WSM or .338 Federal.
Will you be taking shorter shots in tight cover? If so, then velocity is not your top priority. Take a look at bigger, heavier bullets. The trusty 30-30 Win. has probably taken more deer over the years than any other caliber.
-- From Federal Premium Ammunition